Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| L946S | PDR1 | C. glabrata | Validated | Site-directed mutagenesis, gene expression analysis | 21193550 |
L946S amino acid substitution resulted in upregulation of CgCDR1, CgPDH1, and CgSNQ2 suggesting it activates ABC transporter expression that leads to azole resistance | 2 |