Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| L630I | FKS1 | C. glabrata | Validated | Animal study | 22948870 |
L630I mutation alters β-1,3-D-glucan synthase, reducing echinocandin binding affinity, causing resistance | 2 |