Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| L370S | ERG11 | C. albicans | Validated | In-silico Site-Directed Mutagenesis; Molecular Dynamics Simulation | 35747333 |
L370S mutation disrupts heme binding, reducing fluconazole affinity and causing drug resistance. | 2 |