Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| L344S | PDR1 | C. glabrata | Validated | Microarray Analysis; Ectopic Expression of CgPDR1 in CgPDR1-disrupted strains; qRT-PCR | 20547810;29464833;32563123 |
L344S mutation enhances drug efflux pump expression, reducing intracellular azole concentration and conferring resistance. | 2 |