Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| L280F | PDR1 | C. glabrata | Validated | Microarray Analysis; RT-qPCR; Adherence Assays | 20547810;32563123 |
L280F gain-of-function PDR1 leads to overexpression of ABC transporters, reducing intracellular azole concentration and increasing resistance, while also enhancing adherence via EPA1. | 2 |