Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| K684E | UPC2 | C. albicans | Validated | RT-PCR | 24051054 |
K684E mutation in UPC2 enhances ERG11 expression, increasing target enzyme production and reducing azole efficacy, causing resistance | 2 |