Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| K274Q | PDR1 | C. glabrata | Validated | cgPDR1 gene disruption, gene expression analysis of cgPDR1 mutatnt by qRT-PCR | 29087506 |
K274Q mutation disrupts its inhibitory domain, leading to hyperactivation of drug efflux pumps, increased azole efflux, conferring resistance | 2 |