Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| K274N | PDR1 | C. glabrata | Validated | Site-directed mutagenesis, gene expression analysis | 21193550 |
The mutation confers in upregulation of cgCDR1, thus activating ABC transporter expression and leading to increase azole expresssion | 2 |