Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| K143R | ERG11 | C. parapsilosis | Validated | RT-PCR | 11557454;16201925;24051054 |
K143R mutation reduces fluconazole affinity by altering the Erg11p enzyme's binding site, potentially combined with efflux pump upregulation. | 2 |