Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| K143Q | ERG11 | C. albicans | Validated | Site-Directed Mutagenesis; Heterologous Expression | 23480635 25748216 |
The K143Q mutation in ERG11 reduces azole binding affinity, causing azole resistance. | 2 |