Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| I803T | PDR1 | C. glabrata | Validated | Site-directed mutagenesis, transcriptome and genomic profiling of isolates | 35532173 |
I803T gain-of-function mutation upregulates drug efflux pumps (CgCDR1, CgPDH1), enhancing azole resistance by activating target genes independently of drug presence and altering CgPdr1 interactions. | 2 |