Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| I392M | PDR1 | C. glabrata | Validated | Ectopic Expression in Δpdr1 Background | 35532173 |
I392M is a gaain of function mutation that activates CgPdr1, upregulating efflux pump genes and conferring azole resistance. | 2 |