Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| H741Y | TAC1 | C. albicans | Validated | mRNA Expression Analysis (Northern blotting); Protein Expression Analysis (Western blotting) | 20876623 |
H741Y in TAC1 increases CDR1/CDR2 expression, enhancing efflux pump activity and azole resistance | 2 |