Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| H59D | FCY1 | C. glabrata | Validated | Structural analysis; Cytosine Assimilation Assay | 20823283 |
H59D mutation impairs cytosine deaminase activity, reducing 5FC conversion to 5FU, causing resistance | 2 |