Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| H576Y | PDR1 | C. glabrata | Validated | qRT-PCR | 19196495 27744635 35577042 |
The H576Y gain-of-function mutation in CgPdr1p enhances the expression of CgCDR1 and CgCDR2, boosting efflux pump activity and contributing to azole resistance. | 2 |