Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| H283R | ERG11 | C. albicans | Validated | Functional expression assays | 15611610 |
H283R mutation alters the enzyme's structure, reducing binding affinity and contributes to cross-resistance to azole. | 2 |