Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| H269N | ERG3 | C. dubliniensis | Validated | Heterologous expression in Saccharomyces cerevisiae | 12878500 |
H269N mutation disrupts sterol C5,6-desaturase function, altering sterol biosynthesis leading to itraconazole resistance. | 2 |