Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| H263Y | TAC1 | C. albicans | Validated | Site-directed mutagenesis | 31923309 |
H263Y mutation enhances Tac1p activity, leading to overexpression of CDR1 and CDR2 efflux pumps leading to azole resistance. | 2 |