Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| G648S | UPC2 | C. albicans | Validated | qRT-PCR Analysis; Genome-wide Transcriptional Analysis | 22923048 25385095 |
The G648S mutation in UPC2 enhances Upc2p activity, leading to ERG11 overexpression, increased ergosterol production, efflux pump upregulation, and resistance to azoles and terbinafine. | 2 |