Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| G648D | UPC2 | C. albicans | Validated | Gene expression profiling; Proteomic analysis; Microarray Analysis | 18487346 22923048 31923309 |
G648D enhances ergosterol biosynthesis and upregulates MDR1 and CDR11,conferring azole resistance. | 2 |