Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| G583R | MRR1 | C. parapsilosis | Validated | Gene expression analysis | 26248365 |
The G583R mutation in MRR1 upregulates MDR1 efflux pump expression, reducing intracellular azole drug levels and conferring resistance. | 2 |