Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| G464S | ERG11 | C. tropicalis | Validated | Functional Expression in Saccharomyces cerevisiae | 11557454 |
G464S mutation reduces azole binding affinity by altering enzyme structure, leading to high-level fluconazole resistance | 2 |