Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| G464D | ERG11 | C. tropicalis | Validated | Sterol Analysis | 23877676 |
G464D disrupts Erg11p binding, causing azole resistance and sterol alterations, leading to cross-resistance with amphotericin B | 2 |