Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| G346D | PDR1 | C. glabrata | Validated | Gene Expression Analysis | 35577042 |
The gain-of-function G346D mutation causes overexpression of efflux pumps such as CDR1, CDR2, and SNQ2 contributing to azole resistance. | 2 |