Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| G307S | ERG11 | C. albicans | Validated | Cloning and Expression; Expression in S. cerevisiae; Statistical Comparison | 15155210 |
G307S mutation decreases fluconazole susceptibility by altering the lanosterol 14α-demethylase enzyme's affinity for azoles. | 2 |