Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| G210D | FUR1 | C. glabrata | Validated | Structural analysis; Cytosine Assimilation Assay | 20823283 |
G210D mutation impairs UPRT function, reducing 5FC activation into toxic metabolites, leading to resistance without affecting cell viability. | 2 |