Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| G122S | ERG2 | C. glabrata | Validated | Sterol Analysis | 30455247 |
G122S mutation disrupts ergosterol biosynthesis, leading to amphotericin B resistance by accumulating fecosterol and impairing C-8 sterol isomerase. | 2 |