Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| G11D | FCY1 | C. glabrata | Validated | Structural analysis; Cytosine Assimilation Assay | 20823283 |
G11D mutation inactivates cytosine deaminase, blocking 5FC conversion to toxic 5FU, impairing substrate entry, causing resistance. | 2 |