Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| F659V | FKS2 | C. glabrata | Validated | qRT-PCR; Murine model | 19546367;23487382
|
F659V mutation in Fks2 alters β-1,3-glucan synthase, reducing echinocandin binding and decreasing drug susceptibility. | 2 |