Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| F641del | FKS1 | C. kefyr | Validated | Glucan Synthase Inhibition Assays | 24982083 |
The F641del mutation reduces echinocandin binding to the GS enzyme complex by disrupting the interaction between Fks1p and the drugs. | 2 |