Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| F635Y | FKS1 | C. auris | Validated | Murine model, Kaplan-Meier estimator, Chitin content estimation | 34780273 36975998 |
F635Y mutation reduces echinocandin susceptibility by altering 1,3-β-d-glucan synthase, leading to high-level caspofungin resistance. | 2 |