Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| F575L | PDR1 | C. glabrata | Validated | Gene substitution experiments; Northern blot analyses; qRT-PCR | 16569856 |
F575L mutation upregulates CgPDR1 expression, increasing CgCDR1-mediated efflux of azole drugs, which reduces their intracellular concentration and confers resistance. | 2 |