Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| F449V | ERG11 | C. albicans | Validated | Plasmid construction for allele sequencing | 25385095 |
F449V mutation alters the fungus-specific external loop, reducing fluconazole binding affinity, conferring resistance. | 2 |