Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| F1235C | CDR1 | C. albicans | Validated | R6G efflux analysis | 30348662 |
F1235C mutation alters transporter conformation in TMS8, enabling FK506 co-transport, maintaining drug efflux, and conferring FK506 resistance | 2 |