Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| E841G | TAC1 | C. albicans | Validated | Flow cytometric analysis of rhodamine 6G efflux, qrT-PCR analysis | 24051054 |
E841G mutation in TAC1 enhances CDR1 expression, increasing azole efflux and reducing intracellular drug concentration. | 2 |