Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| E655K | FKS2 | C. glabrata | Validated | Animal studies | 31711370 |
E655K mutation alters the structure of 1,3-β-D-glucan synthase, reducing echinocandin binding affinity, causing resistance | 2 |