Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| E655A | FKS2 | C. glabrata | Validated | Phenotypic Analysis | 29311063 |
The E655A mutation alters the β-(1,3)-D-glucan synthase enzyme, reducing its affinity for echinocandins, leading to resistance. | 2 |