Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| E555K | PDR1 | C. glabrata | Validated | Gene Expression Analysis; Ectopic Expression | 35532173 35577042 |
The E555K mutation leads to the constitutive activation of efflux pumps, reducing azole drug concentrations and conferring resistance. | 2 |