Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| E517Q | ERG11 | C. albicans | Validated | qRT-PCR | 36654793 |
E517Q mutation reduces azole binding to 14α-demethylase, contributing to resistance, though additional mechanisms like efflux pumps and ergosterol pathway alterations may also play a role. | 2 |