Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| E1083Q | PDR1 | C. glabrata | Validated | Analysis of ABC-transporter gene expression; In vivo studies; Structural analysis | 19148266 27020939 |
The E1083Q gain-of-function mutation in CgPdr1p enhances the expression of ABC-transporter genes (CgCDR1, CgCDR2, CgSNQ2), boosting efflux pump activity and promoting azole resistance. | 2 |