Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| D876Y | PDR1 | C. glabrata | Validated | Analysis of ABC-transporter gene expression | 19148266 27020939 |
The D876Y gain-of-function mutation in CgPdr1p increases the expression of ABC-transporter genes (CgCDR1, CgCDR2), enhancing efflux pump activity and azole resistance. | 2 |