Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| D666G | FKS2 | C. glabrata | Validated | Genetic Analysis; Enzyme Inhibition Assays; Kinetic Analysis; In vivo Studies; MALDI-ToF MS | 19546367 22203604 28831086 |
The D666G mutation in Fks2p reduces echinocandin drug sensitivity by altering 1,3-β-D-glucan synthase enzyme kinetics, decreasing drug affinity, and increasing MIC/IC50 values. | 2 |