Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| D632G | FKS1 | C. glabrata | Validated | Genetic Analysis; Enzyme Inhibition Assays; Kinetic Analysis | 19546367 24323472 24829248 |
The D632G mutation in Fks1p alters 1,3-β-D-glucan synthase structure, reducing drug affinity and catalytic efficiency, leading to echinocandin resistance. | 2 |