Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| D19E | ERG3 | C. albicans | Validated | Sterol estimation by GC-MS, R6G efflux | 19089303 |
D19E mutation reduces sterol C-5 desaturase activity, leading to sterol intermediate accumulation and decreased ergosterol, conferring resistance to FLC, AMB, and nystatin. | 2 |