Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| C866Y | MRR1 | C. dubliniensis | Validated | Expression of Mutated MRR1 Alleles in C. albicans | 18809934 |
C866Y mutation causes overexpression of the MDR1 gene, leading to increased efflux pump activity resulting in resistance. | 2 |