Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| C198F | ERG6 | C. glabrata | Validated | Sterol analysis | 30455247 |
C198F mutation disrupts ergosterol biosynthesis, leading to polyene resistance, sterol accumulation, and pseudohyphal growth due to altered membrane composition. | 2 |