Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| A643V | UPC2 | C. albicans | Validated | Site-directed mutagenesis, qRT-PCR | 22923048 25385095 28461316 |
A643V mutation in UPC2 enhances ERG11 and MDR1 expression, increasing ergosterol synthesis and drug efflux, leading to azole resistance. | 2 |