Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| A446Y | UPC2 | C. albicans | Validated | Estimation of plasma membrane ergosterol content | 39059553 |
A446Y mutation alters its ligand binding domain, disrupting ergosterol interaction, leading to increased ergosterol synthesis conferring resistance | 2 |