Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| A122V | ERG11 | C. krusei | Validated | Flow Cytometry; Murine model; RT-PCR | 31932372 |
The A122V mutation in ERG11 reduces azole affinity by altering the protein structure near the binding site, contributing to azole resistance. | 2 |